Directed Evolution of Mutator Adenoviruses Resistant to Antibody Neutralization
نویسندگان
چکیده
منابع مشابه
Directed adenovirus evolution using engineered mutator viral polymerases
Adenoviruses (Ads) are the most frequently used viruses for oncolytic and gene therapy purposes. Most Ad-based vectors have been generated through rational design. Although this led to significant vector improvements, it is often hampered by an insufficient understanding of Ad's intricate functions and interactions. Here, to evade this issue, we adopted a novel, mutator Ad polymerase-based, 'ac...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X
DOI: 10.1128/jvi.00473-13